Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist
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چکیده
منابع مشابه
Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
Introduction: Anxiety is among the most common and treatable mental disorders. Adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid CB1 receptor antagonist (AM251) i...
متن کاملSR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.
In the present report, we investigated in detail the effects of SR 144528, a selective antagonist of the peripheral cannabinoid receptor (CB2), on two well-characterized functions mediated by CB2: the induction of the early response gene krox24 and the inhibition of adenylyl cyclase. We generated Chinese hamster ovary cells doubly transfected with human CB2 and a luciferase reporter gene linked...
متن کاملinteraction between antagonist of cannabinoid receptor and antagonist of adrenergic receptor on anxiety in male rat
introduction: anxiety is among the most common and treatable mental disorders. adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. the elevated plus-maze (epm) has broadly been used to investigate anxiolytic and anxiogenic compounds. the present study investigated the effects of intraperitoneal (ip) injection of cannabinoid cb1 receptor antagonist (am251) i...
متن کاملmidazolam-induced learning and memory impairment is modulated by cannabinoid cb1 receptor agonist and antagonist
background: memory impairment is a well-known effect of many benzodiazepine compounds which is mediated through their action on gamma-aminobutyric acid type a (gabaa) receptors. on the other hand, cannabinoids can affect learning and memory process through presynaptic modulation of the release of both excitatory glutamate and inhibitory gaba transmitters in brain regions involved in learning an...
متن کامل2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Two types of endogenous cannabinoid-receptor agonists have been identified thus far. They are the ethanolamides of polyunsaturated fatty acids--arachidonoyl ethanolamide (anandamide) is the best known compound in the amide series--and 2-arachidonoyl glycerol, the only known endocannabinoid in the ester series. We report now an example of a third, ether-type endocannabinoid, 2-arachidonyl glycer...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1997
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0701303